Fig. 5

Structural equation model for direct, indirect and mediation relationship. Ellipses: latent variables; boxes: observed variables. CON the cingulo-opercular network, DAN the dorsal attention network, DMN the default mode network, SAN the salience network, SMN the sensory network, SUB the subcortical network; VAN the ventral attention network, VIS the visual network, Aβ amyloid-1 to 42 peptides, T_Tau total tau, P_Tau tau phosphorylated at the threonine 181 position, MMSE mini-mental state examination, ADAS-Cog Alzheimer’s Disease Assessment Scale-Cognitive Subscale. The abbreviations of plasma cholesterol metabolites were are provided in Additional file 1: Table S2