Fig. 4

Lipid-associated imaging biomarker for classifying AD spectrum. A Twenty-two functional connections were used for classification between groups. Node colors represent Power-atlas cortical and subcortical regions consisting of ten RSNs. B Functional connections that showed group-level differences were used as the inputs for binary classification. All p values of area under curve were < 0.001. AUD the auditory network, CON the cingulo-opercular network, DAN the dorsal attention network, DMN the default mode network, FPN the fronto-parietal network, SAN the salience network, SMN the sensory network, SUB the subcortical network, VAN the ventral attention network, VIS the visual network, ROC receiver operating characteristic, TPR true positive rate, FPR false positive rate, CN cognitively normal, EMCI early mild cognitive impairment, LMCI late mild cognitive impairment, AD Alzheimer’s disease