Fig. 2

Network roles (F) in brain networks of CN (A), EMCI (B), LMCI (C), and AD (D); Dynamic trajectory of network role of large-scale RSNs within- and pairwise between-network connectivity matrices of the four groups (G); A Line chart (H) displays the dynamic trajectory of within- and one-versus-all-other network connectivity across the entire ADS; P value matrix of group differences in within-, one-versus-all-others-, and pairwise between-network connectivity in the ADS (F); Circos plot representation of significant group-level differences of neural connections among the ten RSNs in the ADS using the NBS method (I and J). Blue lines indicate decreased connectivity and red indicates increased connectivity in the ADS. AUD the auditory network, CON the cingulo-opercular network, DAN the dorsal attention network, DMN the default mode network, FPN the fronto-parietal network, SAN the salience network, SMN the sensory network, SUB the subcortical network, VAN the ventral attention network, VIS the visual network