Skip to main content
Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Dyslipidemia induced large-scale network connectivity abnormality facilitates cognitive decline in the Alzheimer’s disease

Fig. 1

Regression analyses between polygenic scores, cerebrospinal fluid biomarkers, plasma cholesterol metabolites, and general cognition in the AD spectrum. A Nonlinear correlations were plotted in heat map between blood cholesterol metabolites and cognitive scores. The color bar indicated nonlinear regression p values ranging from 0 to 1. Two-tailed p values < 0.1 were considered significant. B Significant linear correlations were found between three cholesterol metabolism related markers in the blood and Tau level of cerebrospinal fluid in the AD spectrum. C Linear regression between polygenic scores and cerebrospinal fluid biomarkers revealed that GRS was significantly correlated with Aβ, Tau, and even p-Tau levels, in the contrast, GPS was not correlated with any of cerebrospinal fluid biomarkers; while relative risk scores (RRS = GRS—GPS) was significantly influenced the Aβ, Tau but not p-Tau levels in the AD spectrum. Grey bands indicated 95% confidence intervals and binomial nonlinear regressions were applied in Fig. 1B and 1C. Two-tailed p values < 0.1 were considered significant in Fig. 1B and 1C. The abbreviations of plasma cholesterol metabolites were are provided in Additional file 1: Table S2. amyloid 1 to 42 peptide, Tau total tau, pTau tau phosphorylated at the threonine 181 position, MMSE Mini-mental state examination, ADAS-Cog Alzheimer’s Disease Assessment Scale- Cognitive subscale, GRS genetic risk score including APOE, GPS genetic protective score, RRS relative risk score

Back to article page