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Table 2 Univariable and multivariable analysis for OS on the discovery set and the three external validation sets

From: Multi-scale pathology image texture signature is a prognostic factor for resectable lung adenocarcinoma: a multi-center, retrospective study

 

Discovery set

Validation set V1

Validation set V2

Validation set V3

 

HR (95%CI)

P-value

HR (95%CI)

P-value

HR (95%CI)

P-value

HR (95%CI)

P-value

Univariable Analysis

 Age

   < 65 years vs. ≥ 65 years

1.54(0.76–3.11)

0.2309

1.20(0.49–2.93)

0.6910

1.20(0.61–2.37)

0.5907

1.17(0.76–1.83)

0.4753

Sex

 Male vs. Female

0.62(0.30–1.28)

0.1962

0.95(0.46–1.95)

0.8944

0.40(0.20–0.84)

0.0149

0.69(0.45–1.08)

0.1041

Smoking status

 Never vs. Ever

1.51(0.72–3.15)

0.2730

0.69(0.32–1.51)

0.3514

2.15(1.11–4.20)

0.0241

1.77(0.77–4.08)

0.1814

Tumor site

 Upper/Middle vs. Lower

0.83(0.39–1.76)

0.6205

0.99(0.48–2.05)

0.9865

0.70(0.35–1.37)

0.2940

1.30(0.83–2.04)

0.2474

Treatment

 Surg. vs. Surg. + Chemo

4.46 (2.16–9.24)

 < 0.0001

1.78(0.85–3.75)

0.1268

1.47(0.76–2.87)

0.2539

1.92(1.19–3.08)

0.0074

Differentiation

 G1/G2 vs. G3/G4

7.00(3.40–14.40)

 < 0.0001

1.60(0.74–3.46)

0.2296

3.07(1.58–5.97)

0.0010

NA

 

TNM stage

 II vs. I

4.93(1.90–12.81)

0.0011

2.67(0.97–7.35)

0.0572

1.20(0.53–2.72)

0.6669

2.88(1.75–4.72)

 < 0.0001

 III vs. I

9.82(4.33–22.28)

 < 0.0001

4.55(2.02–10.26)

0.0003

2.51(1.16–5.47)

0.0201

3.54(1.95–6.41)

 < 0.0001

MPIS

 Low vs. High

9.90(3.44–28.49)

 < 0.0001

2.36(1.08–5.16)

0.0312

3.47(1.60–7.52)

0.0016

2.57(1.59–4.17)

0.0001

Multivariable analysis

 Differentiation

  G1/G2 vs. G3/G4

2.47(1.12–5.49)

0.0259

  

3.49(1.72–7.06)

0.0005

NA

 

TNM stage

 II vs. I

2.72(0.99–7.44)

0.0521

2.60(0.87–7.78)

0.0871

1.25(0.54–2.87)

0.6031

2.20 (1.30–3.74)

0.0035

 III vs. I

3.12(1.23–7.92)

0.0166

5.30(2.22–12.66)

0.0002

3.24(1.45–7.28)

0.0043

3.08 (1.68–5.64)

0.0003

MPIS

 Low vs. High

5.32(1.72–16.44)

0.0037

2.63(1.10–6.29)

0.0292

2.99(1.34–6.66)

0.0075

1.93 (1.15–3.23)

0.0125

  1. HR hazard ratio, CI confidence interval, Surg. + Chemo surgery and chemotherapy, G1/G2 well-moderately differentiated, G3/G4 poorly undifferentiated, NA not applicable
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Journal of Translational Medicine

ISSN: 1479-5876

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