Fig. 7

Immunohistochemical staining for AKR1B1, ITGAV, TGFβ1 and G6PD in ovarian tumor samples collected from patients with platinum sensitive and resistant disease. Immunohistochemistry for AKR1B1, ITGAV, TGFβ1 and G6PD was performed on 15 platinum-sensitive and 10 platinum-resistant tumor tissues collected from ovarian cancer patients. A Representative images of staining on platinum-sensitive and platinum-resistant tumor tissues collected from ovarian cancer patients were displayed at 20 × magnification; scale bar = 100 μm. Quantification of DAB staining for B AKR1B1, ITGAV, TGFβ1 and G6PD was performed using Aperio ImageScope software; mean ± SD; Mann–Whitney test; outliers greater than 2 SD are excluded where n = 13–14 in platinum-sensitive group. B *p < 0.05, **p < 0.01 when compared to platinum-sensitive group