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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

Fig. 8

SC79 reversed the effects of knocking down PSAT1 on the osteogenic differentiation of PDLSCs. A The phosphorylation level of Akt and GSK3β, and the protein level of active-β-catenin were analyzed in PDLSCs. B The quantitative analysis of ALP activity in PDLSCs after osteogenic induction. C ALP staining of PDLSCs after osteogenic induction for 7 days. D Alizarin red staining of PDLSCs after osteogenic induction for 21 days. E Quantitative analysis of mineralized matrix after osteogenic induction for 21 days. F The protein levels of COL1A1, ALP and RUNX2 in PDLSCs after osteogenic induction for 7 days. G The mRNA levels of COL1A1, ALP and RUNX2 in PDLSCs after osteogenic induction for 7 days. shPSAT1: PDLSCs with PSAT1 knocked down. shNC: control PDLSCs. *p < 0.05; **p < 0.01

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Journal of Translational Medicine

ISSN: 1479-5876

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