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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

Fig. 6

PSAT1 regulated Akt/GSK3β/β-catenin signaling pathway in PDLSCs. A The phosphorylation level of Erk, Akt, and GSK3β, and the protein level of active-β-catenin were analyzed in PDLSCs with PSAT1 overexpressed. B The phosphorylation level of Erk, Akt, and GSK3β, and the protein level of active-β-catenin were analyzed in PDLSCs with PSAT1 knocked down. C Western Blot analysis of β-Catenin protein in nucleus and cytoplasm after PSAT1 was overexpressed. D Western Blot analysis of β-Catenin protein in nucleus and cytoplasm after PSAT1 was knocked down. OEPSAT1: PDLSCs with PSAT1 overexpressed. OENC: control PDLSCs for OEPSAT1 PDLSCs. shPSAT1: PDLSCs with PSAT1 knocked down. shNC: control PDLSCs for shPSAT1 PDLSCs. *p < 0.05; **p < 0.01

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