Table 5 Comparison of different radiotherapy techniques for irradiation of rHNC

IMRT

Oropharyngeal;

Neck

49–70

2-year LC: 46–57%;

2-year OS: 41–50%

Grade ≥ 3 late toxicities: 14.2–57.1%;

Grade 5 late toxicities: 1.3–7.4%

SBRT

Neck;

Oral cavity

30–48

2-year LRC: 31.7–64%;

1-year OS: 32–58.9%;

2-year OS: 16–35%;

Median OS: 7.5–14.4 mo

Grade ≥ 3 toxicities: 4.7–21%

HDR-BRT

Neck;

Oral cavity;

12–36.5

1-year LC: 55–77%;

2-year LC: 62–67%;

1-year OS: 63–77%;

2-year OS: 42–67%;

Median OS: 8.5–33.4 mo

Grade ≥ 3 toxicities: 0–34.4%

LDR-BRT

Neck;

Nasopharynx

D90: 117–157.5

1-year LC: 40.6–75.2%;

2-year LC: 27.5- 49.9%;

1-year OS: 42.5–70.8%;

2-year OS: 18.2–39%;

Median LC: 10–24 mo;

Median OS: 11–28 mo

Grade ≥ 3 toxicities: 0–9.9%

Irradiation with systemic therapy

Oropharynx;

Oral cavity

27–60

1-year LC: 46.4–78.6%;

1-year OS: 23–85%;

2-year OS: 10–67%;

Median OS: 6–37.4 mo

Grade ≥ 3 toxicities: 5.8–57.6%