Fig. 7From: Discovery of a pyrano[2,3-b]pyridine derivative YX-2102 as a cannabinoid receptor 2 agonist for alleviating lung fibrosis A schematic representation of the antifibrotic effect of YX-2102 in the inhibition of lung alveolar EMT. Activation of CB2R by YX-2102 treatment promotes the translocation of Nrf2 to the nucleus, which subsequently reduced oxidative stress and elevating Smad7 protein levels, thereby inhibiting Smad2/3 phosphorylation to block TGF-β signaling. These consecutive events result in EMT suppression in lung alveolar epithelial cells and ultimately attenuates bleomycin-induced pulmonary fibrosisBack to article page