Fig. 4

Validation of the age association with Immune-checkpoint-hepatitis in another cohort of 67 patients (validation cohort). A Pie charts depicting the percentage of patients with therapy-induced hepatitis. B Kaplan–Meier analysis of hepatitis events in young patients (< 55, n = 24) and aged patients (≥ 55, n = 43). C Dot plot describing the age of patients without hepatitis, or who developed mild hepatitis(CTC-AE 1–2) or severe hepatitis (CTC-AE 3–4) Statistics were performed by log-rank test (B) and Kruskal–Wallis test (C)