Fig. 2

Hepatic irAE frequently co-occur with other irAE and are associated with age. A Heatmap displaying the distribution of Hepatitis, skin abnormality, thyroiditis, enteritis and hypophysitis across tumor response, gender and age. Events are highlighted in dark purple. B Table showing the absolute number of patients who developed thyroiditis, hypophysitis, skin abnormality or enteritis grouped by the incidence of hepatitis. C Table showing number of patients with and without top 5 ir-AEs across age groups. Statistics were determined by Fisher’s exact test in B and chi square test in C