Table 4 Over-Representation Analysis of Gene-ontology biological process terms and Reactome pathways associated with CIPN
From: Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study
Gene Set | Description | Enrichment Ratio | P-Value | FDRa |
|---|---|---|---|---|
Gene-ontology Biological Process Terms | ||||
GO:0007215 | glutamate receptor signaling pathway | 2.8127 | 4.21E−10 | 3.58E−07 |
GO:0034765 | regulation of ion transmembrane transport | 1.6919 | 5.54E−09 | 1.7765E−06 |
GO:0061564 | axon development | 1.645 | 8.01E−09 | 1.7765E−06 |
GO:0003013 | circulatory system process | 1.6516 | 8.36E−09 | 1.7765E−06 |
GO:0001655 | urogenital system development | 1.7983 | 1.18E−08 | 2.0012E−06 |
GO:0099177 | regulation of trans-synaptic signaling | 1.6614 | 5.31E−08 | 7.0381E−06 |
GO:0006898 | receptor-mediated endocytosis | 1.8105 | 5.80E−08 | 7.0381E−06 |
GO:0048880 | sensory system development | 1.6889 | 1.91E−07 | 0.000020307 |
GO:0030900 | forebrain development | 1.6521 | 3.53E−07 | 0.000033325 |
GO:0042391 | regulation of membrane potential | 1.593 | 9.14E−07 | 0.000077663 |
Reactome Pathways | ||||
R-HSA-112316 | Neuronal System | 1.8569 | 1.92E−10 | 3.33E−07 |
R-HSA-382551 | Transport of small molecules | 1.5466 | 2.12E−09 | 1.8316E−06 |
R-HSA-5576891 | Cardiac conduction | 2.2029 | 1.02E−07 | 0.000058763 |
R-HSA-109582 | Hemostasis | 1.5141 | 1.76E−07 | 0.000064244 |
R-HSA-983712 | Ion channel transport | 2.004 | 1.96E−07 | 0.000064244 |
R-HSA-397014 | Muscle contraction | 1.9434 | 2.23E−07 | 0.000064244 |
R-HSA-112315 | Transmission across Chemical Synapses | 1.8549 | 6.46E−07 | 0.00015938 |
R-HSA-442660 | Na + /Cl- dependent neurotransmitter transporters | 4.3595 | 1.53E−06 | 0.00033152 |
R-HSA-1474244 | Extracellular matrix organization | 1.697 | 1.84E−06 | 0.00035267 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 1.7388 | 2.72E−06 | 0.00047018 |