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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study

Fig. 1

A) Manhattan plot showing the unadjusted P-value for the association of all SNPs with patient-reported CIPN (EORTC-QLQ-CIPN20). GWAS identified four loci that exceeded genome-wide significance of P < 5 × 10–8 (red circles). B) Distribution of top associated SNPs from EORTC-QLQ-CIPN20 GWAS (P < 10–5 cut-off) into functional categories including known genes, non-coding RNAs and intergenic variants within regulatory elements. C) Bar plot for PRS calculated for each P-value range and their correlation with the patient-reported scores. The corresponding number of SNPs that fall within each threshold is indicated in brackets

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