Table 4 COVID-19 Convalescent Plasma Donor Demographics Comparing P1, P2 Perturbed Sample Clusters (P1, P2) with Other CCD and Healthy Donors
From: Longitudinal transcriptional analysis of peripheral blood leukocytes in COVID-19 convalescent donors
HD | P1 | P2 | Other CCD | P Value | |
|---|---|---|---|---|---|
Number | 40 | 8* | 13 | 249* | |
Age (years) | 50.9 ± 14.5 | 47.8 ± 12.9 | 47.3 ± 14.6 | 49.3 ± 14.9 | 0.9003 |
Sex (n, %) | |||||
Male | 23 (57.5) | 5 (62.5) | 10 (76.9) | 110 (44.1) | - |
Female | 17 (42.5) | 3 (37.5) | 3 (23.1) | 139 (55.8) | - |
Ethnicity (n, %) | |||||
Caucasian | 25 (62.5) | 5 (62.5) | 10 (78.5) | 180 (72.2) | - |
African American | 7 (17.5) | 17 (6.82) | - | ||
Asian | 5 (12.5) | 1 (12.5) | 1 (7.69) | 19 (7.63) | - |
Hispanic | 2 (5) | 1 (7.69) | 19 (7.63) | - | |
Mixed | 2 (25) | 6 (2.4) | - | ||
Others | 1 (2.5) | 6 (2.4) | - | ||
Declined | - | 1 (7.1) | 1 (0.4) | - | |
Unknown | - | 1 (0.4) | - | ||
BMI | 25.1 ± 2.5 | 26.5 ± 5.9 | 27.8 ± 6.2 | 0.3663 | |
Severity (n, %) | |||||
Mild | - | 7 (87.5) | 11 (84.6) | 219 (87.9) | |
Moderate | - | 2 (15.3) | 20 (8) | ||
Severe | - | 9 (3.6) | |||
Asymptomatic | - | 1 (12.5) | 1 (0.4) | ||
Cell counts at baseline# | |||||
WBC | 5.1 ± 1.4 | 6.0 ± 1.0 | 6.3 ± 1.9 | 6.2 ± 1.4 | 0.0186 |
Hemoglobin | 13.7 ± 1.6 | 13.7 ± 0.5 | 14.3 ± 0.9 | 13.6 ± 1.2 | 0.3501 |
Platelets | 231.2 ± 54.2 | 214.4 ± 14.8 | 241.4 ± 53.7 | 231.8 ± 50.4 | 0.6972 |
Neutrophil Absolute (ANC) | 2.8 ± 0.8 | 3.5 ± 0.9 | 3.9 ± 1.8 | 3.6 ± 1.0 | 0.1345 |
Lymphocytes Absolute (ALC) | 1.3 ± 0.2 | 1.7 ± 0.6 | 1.6 ± 0.3 | 1.8 ± 0.5 | 0.0476 |
Monocytes Absolute (AMC) | 0.34 ± 0.08 | 0.5 ± 0.07 | 0.4 ± 0.1 | 0.5 ± 0.1 | 0.0003 |
Eosinophils Absolute | 0.20 ± 0.07 | 0.14 ± 0.1 | 0.16 ± 0.1 | 0.15 ± 0.1 | 0.6322 |
Basophils Absolute | 0.04 ± 0.01 | 0.04 ± 0.01 | 0.04 ± 0.02 | 0.04 ± 0.02 | 0.9957 |
Anti-SARS-Cov2 | |||||
Total Anti-SARS-CoV-2 | 164.6 ± 158.0 | 409.9 ± 323.4 | 399.1 ± 300.5 | 0.0917 | |
IgG Anti-SARS-CoV-2 | 5.3 ± 5.2 | 10.9 ± 6.1 | 10.8 ± 7.6 | 0.1285 | |