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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy

Fig. 6

HRS treatment attenuated mitochondrial dysfunction in septic rats 48 h after LPS administration. A Measurement of MMP damage detected by JC-1 dye showing up-regulation of monomer/J-aggregate in the LPS group (implying increased MMP damage), while HRS treatment showed the reversed effects. B, C ATP content detection in serum and brain tissues of septic rats, depicting decreased ATP content in the LPS group, respectively; this was reversed in the HRS-treated group. D Mitochondrial ROS damage measured by DCFH-DA showing increased DCF fluorescence label in LPS group compared to sham group, which was decreased in the HRS-treated group (n = 6) All data are presented as mean ± SD ****p < 0.0001, ***p < 0.001, **p < 0.005, *p < 0.05. HRS Hydrogen-rich saline, LPS Lipopolysaccharide, ATP Adenosine triphosphate, MMP mitochondrial membrane potential, DCFH-DA Dichloro-dihydro-fluorescein diacetate, ROS Reactive oxygen species

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