Fig. 8

Combination of ZNF416 siRNA-loaded liposomes and SB431542 exerts a synergic effect on silica-induced pulmonary fibrosis. A Strategy for co-administration of ZNF416 siRNA-loaded liposomes and SB431542 in the silica-induced pulmonary fibrosis mouse model. B Quantification of hydroxyproline contents in mice after silica challenge for the indicated group, with ^**p < 0.01 vs. the indicated group. C H&E staining, Masson staining, and Sirius red staining were performed to measure the severity of lung fibrosis. D, E Western blot and qRT‐PCR analysis of fibrotic markers and ZNF416 protein and mRNA level in mouse lung tissues on saline, SiO₂, SiO₂ + siZNF416 liposomes, SiO₂ + siZNF416 liposomes + SB431542 and SiO₂ + scramble liposomes + DMSO group, with ^**p < 0.01 vs. the indicated group