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Table 3 Summary of pathways detected between COVID-19 patients and controls based on the differentially methylated region (DMR) analysis

From: DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome

Hallmark pathway

N

DE

P.DE

FDR

Changes in DMRs (COVID-19 vs controls)

Interferon alpha response

97

34

0.00

0.00

Hypomethylation

Kras signaling up

200

55

0.00

0.03

Hypomethylation

Mitotic spindle

199

68

0.00

0.00

Hypermethylation

  1. Columns represent the following variables: N number of genes in the gene set. DE number of differentially methylated genes, P.DE p-value for over-representation of the gene set, FDR false discovery rate (p < 0.05). Analyzed regions are based on five or more CpGs