DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome

Table 2 Summary of differentially methylated pathways detected between COVID-19 patients and controls based on CpG sites

Hallmark pathway	N	DE	P.DE	FDR	Changes in CpGs (COVID-19 vs. controls)
Interferon gamma response	189	175	0.00	0.00	hypomethylation
Estrogen response early	189	174	0.00	0.02	hypomethylation
Apical surface	39	39	0.00	0.02	hypomethylation
Interferon alpha response	93	87	0.00	0.02	hypomethylation
Uv response dn	140	131.33	0.00	0.02	hypomethylation
Mitotic spindle	188	175	0.000	0.001	hypomethylation

Columns represent the following variables: N number of genes in the gene set, DE number of differentially methylated genes, P.DE p-value for over-representation of the gene set, FDR false discovery rate (p < 0.05)

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