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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type-specific DNA methylation data

Fig. 7

EWAS output comparisons across three models. Panel A. Model 1 adjusted for age and gender. Model 2 adjusted for age, gender, and HiTIMED-projected tumor purity. Model 3 adjusted for age, gender, HiTIMED-projected tumor purity, DC, CD8mem, Bmem, Treg, epithelial, endothelial, and stromal cell proportions. Delta betas larger than 0.3 and FDR smaller than 0.01 were used as the cut-off for statistically significant DMC identification. Panel B. Heatmap with Manhattan distance clustering and colon cancer CIMP subtypes colored were generated per model

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Journal of Translational Medicine

ISSN: 1479-5876

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