Fig. 1

A Log₂TPM expression of IL-6, TNFα, FOSB, and CEBPD in the PCa cohort split by localized and metastatic status. These genes were measured to have significantly differential expression between the localized and metastatic groups (two-tailed student’s t-test). Median and interquartile ranges are shown for each group. B–E heatmaps showing relative expression profiles (mRNA) of selected genes vs. localized/metastatic groupings of 49 PCa patients, where 28 were localized (black) and 21 were metastatic (grey). The genes shown are B TNFα and IL-6, C. AP-1 components D NF-kB and E CEBP family genes. On the right side of the heatmaps we show the Information Coefficient (Δ), a measure of association of each gene/gene set vs. the phenotype and the corresponding permutation-derived p-value. F mean values and standard deviations for all components of the AP-1 complex. G, H single-sample GSEA analysis heatmap showing the Information Coeficient (Δ) association between localized/metastatic groups and the expression of G NF-kB related gene sets and H AP-1 related gene sets. The 5 top scoring gene set are shown