Fig. 6

Factors associated with vector integration in CAR T-cell products. The percentage of integration events at genomic features based on CAR T-cell type in lentiviral (A) and γ-retroviral products (B), and based on CAR T-cells produced from patients with different diseases (C, D). The scatter plots show a correlation between percentage of integration at each genomic features and percentage of CD4⁺ T cells (E), percentage of CD8⁺ T cells (F), vector copy number (G) in CAR T-cells produced with the lentiviral and γ-retroviral vectors. The x-axis indicates coverage percentage (%). The y-axis represents CD4 + T cell percentage (E), CD8 + T cell percentage (F) and Average vector number (G). Pearson correlation coefficients (r) and two-tailed p-value were computed in the GraphPad software