Circular RNAs in organ injury: recent development

Wong, Ryan; Zhang, Yiwen; Zhao, Hailin; Ma, Daqing

doi:10.1186/s12967-022-03725-9

Journal of Translational Medicine

Table 1 Summary of dysregulated circular RNAs in organ injuries

From: Circular RNAs in organ injury: recent development

Organ	Types of injury	CircRNA expression pattern	Downstream regulation	References
CNS
Brain	Traumatic brain injury	circLphn3 downregulated	Improved BBB integrity and promoted inflammatory response	[43]
		circLrp1b downregulated	Inhibits inflammatory response	[45]
		circHtra1 upregulated	Inhibits cell proliferation and promotes cell apoptosis	[46]
	Ischemia/reperfusion injury	circCTNNB1 downregulated	Improves BBB integrity and promotes cell proliferation	[50]
		circFOXO3 upregulated	Promotes autophagy and maintains BBB integrity	[51]
		circCCDC9 downregulated	Improves BBB integrity	[52]
		circUCK2 downregulated	Inhibits cell proliferation and promotes cell apoptosis	[53]
		circCDC14A upregulated	Promotes cell proliferation and migration	[56]
		circUSP36 downregulated	Inhibits cell apoptosis and promoted cell proliferation	[31]
Spinal cord	Spinal cord injury	circHIPK3 downregulated	Inhibits cell proliferation and promotes cell apoptosis	[60]
		circRNA_7079 upregulated	Promotes inflammatory response	[63]
		circRNA_2960 upregulated	Promotes inflammatory response and inhibits cell apoptosis	[65]
Visceral organ
Lung	Idiopathic pulomnary fibrosis	circHIPK3 upregulated	Promotes fibroblast proliferation and lung fibroblast-to-myofibroblast transition	[68]
		hsa_circ_0058493 upregulated	Potential biomarker candiate	[69]
	Silicosis	circZC3H4 upregulated	Regulates fibroblast activation and proliferation	[71]
	Cigarette particle-induced lung injury	circFOXO3 upregulated	Promotes inflammatory response	[74]
		circRNA_0006892 downregulated	Promotes cell apoptosis and inflammatory response	[75]
	Pulmonary hypertension	circRNA_004592 upregulated	Promotes cell proliferation and inhibits cell apoptosis	[79]
	Acute lung injury	hsa_circ_0059930 upregulated	Inhibits cell apoptosis and inhibits cell proliferation	[81]
		circRNA_0001679 upregulated	Promotes cell apoptosis and proinflammatory cytokines	[82]
		circHECTD1 downregulated	Inhibits cell apoptosis	[83]
Kidney	Mesangial cell Injury	circLRP6 upregulated	Promotes inflammatory response	[33]
	Acute kidney injury	circ_0114428 upregulated	Promotes inflammatory response	[90]
		circFANCA upregulated	Promotes cell apoptosis, inflammatory response, oxidative stress	[91]
		circ_RASGEF1B upregulated	Promotes cell apoptosis and inflammatory response	[92]
		circ_BNIP3L upregulated	Promotes inflammatory response and oxidative stress	[93]
		circ_0114427 upregulated	Promotes inflammatory response	[94]
		circSnrk upregulated	Promotes cell apoptosis	[27]
		hsa_circ_010157 upregulated	Promotes cell apoptosis and inflammatory response	[95]
		circTLK1 upregulated	Promotes cell apoptosis, inflammatory response, oxidative stress	[96]
		circHIPK3 upregulated	Promotes cell apoptosis and inflammatory response	[97]
	Ischemia/reperfusion kidney injury	circAKT3 upregulated	Promotes cell apoptosis	[99]
		circ_001839 upregulated	Promotes inflammatory response	[100]
		circ_0023404 upregulated	Promotes cell apoptosis and inflammatory response	[101]
	Renal fibrosis	circPlekha7 downregulated	Promotes cell proliferation	[104]
	Lupus nephritis	circHLA-C upregulated	Promotes lupus nephritis pathogenesis	[106]
Heart	Myocardial ischemia–reperfusion injury	circ_0030235 upregulated	Promotes cell apoptosis	[30]
		circ_0001206 downregulated	Promotes cell apoptosis	[109]
		circSAMD4A upregulated	Promotes cell apoptosis and inflammatory response	[110]
		circFOXO3 downregulated	Inhibits inflammatory response	[111]
		circRbms1 upregulated	Promotes FOXO1 expression	[112]
		circUBXN7 downregulated	Inhibits cell apoptosis and inflammatory response	[113]
		circPostn upregulated	Promotes cell apoptosis	[115]
		circHelz upregulated	Promotes inflammatory response	[116]
	Cardiac fibrosis	circNFIB downregulated	Promotes fibroblast proliferation and cardiac fibroblast-to-myofibroblasts differentiation	[118]
		circRNA_000203 upregulated	Promotes α-SMA, Col1a2 and CTGF expression	[120]
		circHIPK3 upregulated	Promotes α-SMA, Col1a1 and Col3a1 expression	[121]
Liver	Hepatic fibrosis	circPSD3 downregulated	Promotes inflammatory response	[123]
		circ_0067835 upregulated	Promotes cell proliferation	[125]
	Hepatic ischemia–reperfusion injury	circRNA_017753 downregulated	Activates Jade1 signalling pathway	[129]
	Radiation-induced liver Injury	hsa_circ_0071410 upregulated	Promotes cell proliferation	[131]
		circTUBD1 upregulated	Promotes inflammatory response	[133]
		circRSF1 upregulated	Promotes cell proliferation and inflammatory response	[136]
Intestine	Intestinal injury	circRNA_Maml2 downregulated	Promotes cell proliferation, differentiation and migration	[28]
		circHIPK3 downregulated	Inhibits cell proliferation	[139]
Reproductive system
Uterus and ovary	Uterus and ovary injury	circZC3H4 downregulated	Promotes cell apoptosis	[141]
		circScar upregulated	Inhibits cell proliferation	[141]

The table summarised all the discussed circular RNAs in this paper. The expression patterns of each circular RNAs and their corresponding pathological outcomes in each organ injury were shown. Importantly, circFOXO3, circHIPK3 and circZC3H4 were consistently reported in more than one types of organ injuries
Circular RNA, circRNA; CNS, Central nervous system

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ISSN: 1479-5876

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