Fig. 1

Single-cell analysis: the cell clusters and their Marker were obtained by reduced-dimensional and clustering. Twenty-eight cell clusters (A) were obtained after the first level classification, and ten cell types (B) were identified by marker gene annotation. Fourteen cell clusters (D) were obtained after the second-level classification of lymphoid immune cells, and seven cell types (E) were identified by marker gene annotation. Fifteen cell clusters (F) were obtained after the second-level classification of myeloid immune cells, and seven cell types (G) were identified by marker gene annotation. Eighteen cell clusters (H) were obtained from normal epithelial cells after secondary classification, and then nine cell types (I) were identified by marker gene annotation. (C) Heatmap of the expression level of Marker genes from twenty-eight cell types