Fig. 9

Elevated ACE2 expression is a marker of poor prognosis in breast cancer patients receiving chemotherapy. A Waffle Chart of clinicopathological characteristics of breast cancer patients with high and low ACE2 expression. B Kaplan–Meier curves of the RFS and DMFS in BRCA patients receiving chemotherapy with high or low ACE2 expression (KM Plotter database). C Kaplan–Meier curves of the RFS and DMFS in ACE2 high and low expression groups in BRCA patients who did not receive chemotherapy (KM Plotter database). D Kaplan–Meier curves of the RFS and DMFS of systematically untreated BRCA with high or low ACE2 expression (KM Plotter database). E Kaplan–Meier survival analysis of OS in ACE2 high and low expression groups in the METABRIC cohort of breast cancer patients receiving chemotherapy and F breast cancer patients not receiving chemotherapy