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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: Chemotherapy induces ACE2 expression in breast cancer via the ROS-AKT-HIF-1α signaling pathway: a potential prognostic marker for breast cancer patients receiving chemotherapy

Fig. 8

ACE2 is strongly positively correlated with breast cancer drug resistance genes (BRCA-DRGs). A The Venn diagram of common upregulated genes between four groups of drug-resistant cells and breast cancer drug-resistant genes defined by GeneCards. The barplot below Venn diagram shows the detailed number of each gene list. B Heatmap showing the correlation of genes expression in breast cancer drug resistance gene set. C The bubble plot summarizing the correlations between BRCA-DRGs and anticancer drugs. D Kaplan–Meier survival analysis of the signature (BRCA-DRGs) in TCGA-BRCA and (E) METABRIC databases. F Spearman correlation analysis of ACE2 expression and the signature (BRCA-DRGs). Scatter plot showed that the expression of ACE2 and the signature (BRCA-DRGs) was positively correlated in breast cancer drug-resistant cells (R = 0.858, P = 8.25e−08)

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Journal of Translational Medicine

ISSN: 1479-5876

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