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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Chemotherapy induces ACE2 expression in breast cancer via the ROS-AKT-HIF-1α signaling pathway: a potential prognostic marker for breast cancer patients receiving chemotherapy

Fig. 1

ACE2 is highly expressed in drug-resistant breast cancer cells. A Integrative Genomics Viewer (IGV) results showed that drug-resistant cells have substantially more reads mapped onto ACE2 exons compared with the parental cells. B Facet boxplot showing upregulation of ACE2 expression in drug-resistant breast cancer cells (P < 0.05, LogFC > 1). C Western blot analysis of high expression of ACE2 protein in 468/EPR, 468/PTR, SK-BR-3/EPR and BT-474/Lapa cells. D Volcano plot showing differentially expressed genes in 468/MTX and SK-BR-3/EPR cells, with labels indicating ACE2 overexpressed in these cells (P < 0.05, LogFC > 1).

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Journal of Translational Medicine

ISSN: 1479-5876

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