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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Whole-cell tumor vaccines desialylated to uncover tumor antigenic Gal/GalNAc epitopes elicit anti-tumor immunity

Fig. 4

Immune responses elicited by DWCTVs in vivo. a Timeline of vaccination and sample collection. b, c IL-2 and IFNγ plasma levels of vaccinated mice were monitored and detected by ELISA. C The CD4/CD8 ratio of CD3 + T cells in DLNs at the 14th d after vaccination. d, e Quantification of Siglec E and MGL expression on DCs located in DLNs at the 14th d after vaccination. The Siglec-9 + and MGL + DCs are gated on CD11c + CD86 + double-positive cells. Data are presented as mean ± SD (n = 5). Each plot of d–f represents the mean of three technical replicates of a mouse. The statistical test of d–f used is an unpaired t-test. *P < 0.05; ***P < 0.005; ****P < 0.0001

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