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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: A photodynamically sensitized dendritic cell vaccine that promotes the anti-tumor effects of anti-PD-L1 monoclonal antibody in a murine model of head and neck squamous cell carcinoma

Fig. 5

PDT-DC vaccine promoting the anti-tumor effects of anti-PD-L1 mAb by activating immune system. (A) and (B) IHC analyses of tumor tissues for the presence of CD8+, CD4+and Foxp3+ cells (scale bars = 20 µm). (C) and (D) IHC analyses of spleen sections for the CD8+, CD4+and Foxp3+ cells after treating the mice with the indicated agents (scale bars = 20 µm). (E) and (F) Serum levels of IL-12 and IL-6 in mice treated with the indicated agents. Cytokines were measured using ELISA (n = 3). The results of serum levels of IL-12 and IL-6 were obtained from three independent experiments and expressed as the mean ± SD. *P < 0.05, **P < 0.01 vs. control, #P < 0.05,  ##P < 0.01 among the groups. CT: combination treatment.

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