Fig. 4

PDT-DC vaccine enhances tumor regression induced by anti-PD-L1 mAb in vivo. (A) Schematic representation of treatment protocol for HNSCC model. (B) Images of the resected tumors. (C) Tumor growths in mice were measured every three days for each group. (D) Tumor weights after 14days of various treatments. (E) The body weights of mice were measured every three days for each group. (F) H&E staining of the heart, liver, spleen, lung, and kidney on the 14th day after treating with the indicated agents (scale bars = 25 µm). (G) IHC analyses of tumor tissues for the expression of Ki67 (scale bars = 25 µm). ^*P <  0.05, ^**P <  0.01 vs. control;  ^#P < 0.05, ^##P < 0.01 among the groups. CT: combination treatment.