Table 3 Detection of biomarkers from proband urine
From: Novel pathogenic variants in CUBN uncouple proteinuria from renal function
Characteristic | Reference | Result | |
|---|---|---|---|
Range | Proband 1 | Proband 2 | |
Urinary albumin |  < 150 mg/L | 297.85 ± 23.23 | 527.98 ± 384.37 |
Urinary creatinine | – | 8.91 ± 1.57 | 26.514 |
Total 24-h urinary protein |  < 230 mg/24 h | 414 ± 166.88 ↑ | 485 ± 190.92 ↑ |
Urinary albumin/urinary creatinine | 0–30 mg/g | 300.86 ± 42.18 ↑ | 363 ↑ |
Urinary α1-microglobulin |  < 12 mg/L | 27.08 ± 10.48 ↑ | 16.65 ± 8.25 ↑ |
Urinary β2-microglobulin |  < 0.3 mg/L | 0.18 ± 0.08 | 0.1 ± 0.25 |
Urinary transferrin |  < 2 mg/L | 21.60 ± 2.16 ↑ | 39.26 ± 31.52 ↑ |