Fig. 4

BTLA signaling pathway and proportion of BTLA ⁺ pDCs

A–C. Circle plot of BTLA signaling in healthy controls (A), pre-treatment (B), and post-treatment (C) groups. The direction of the arrow indicates the signal sender and receiver and the color of the arrow is the same as that of the sender cell. The edge width corresponds to the strength of the ligand-receptor pairs

D. Proportion of BTLA⁺ pDCs in healthy, pre- and post-treatment groups

E. Violin plot for the tolerance score of Tregs. Tolerance was calculated using the gene set from GO:0002645 (termed ‘positive regulation of tolerance induction’). Asterisks denote the significance of the differences between the groups calculated using the Wilcoxon rank-sum test. p ≤ 0.05 (*), p ≤ 0.01 (**), p ≤ 0.001 (***), p ≤ 0.0001 (****), p ≥ 0.05 (ns)