Fig. 3

Periodontitis-induced transcriptional alterations in adaptive immune, B, CD4T, and CD8T cells

A. UMAP plot of the four B cell subsets: exhausted B cells, switched memory B (switched MB) cells, non-switched memory B (non-switched MB) cells, and plasmablasts

B. UMAP plot of the four CD4⁺ T-cell subsets: T helper 1 (Th1), T helper 17 (Th17), follicular helper T (Tfh), and regulatory T (Treg)

C. UMAP plot of the three CD8⁺ T-cell subsets: central memory T (TCM), effector memory T (TEM), and terminal effector T (TTE) cells

D-F. Dot plot showing differential expression levels of genes in the B cell subtypes (D), CD4T cell subtypes (E), and CD8T cell subtypes (F). Figure descriptions are the same as Fig. 2B-D.

G. The plasma levels of CRIP1, IFITM1, TNF-α, CRP, and ESR in healthy controls and patients with periodontitis were measured using ELISA. P-values were calculated using the Wilcoxon rank-sum test to compare the two groups

H. Relationship between CRIP1 and TNF-α, CRP, and ESR measurements. The Pearson correlation coefficient and p-values were calculated from the correlation test

I. Receiver operating characteristic (ROC) curves of CRIP1 and IFITM1 ROC curve analysis showed a clear distinction between the healthy and periodontitis groups