Fig. 2

Differentially expressed genes in innate immune cells, monocytes, dendritic cells, and NK cells

A. UMAP plot of the three monocyte subsets: classical, non-classical, and intermediate monocytes

B–D. Dot plot showing differential expression levels of genes in each monocyte subtype (B), NK cells (C) and mDCs (D). Displayed genes showed similar expression in control and post-treatment groups, but inverse expression patterns in the pre-treatment group. The color of the dots represents the expression levels of the gene, whereas dot size represents the percent of cells expressing the gene

E. Activity score of positive regulation of lipopolysaccharide-mediated signaling pathway in mDCs. Enrichment of genes with GO term GO:0031666 was calculated using the Wilcoxon rank-sum test. p ≤ 0.1 (•), p ≤ 0.05 (*), p ≤ 0.01 (**), p ≤ 0.001 (***), p ≤ 0.0001 (****), p ≥ 0.05 (ns)