Fig. 1

Composition of peripheral blood mononuclear cells (PBMCs) from healthy donors and pre- and post-treatment periodontitis patients

A. The graphical abstract of this study

B. Bar graph showing cell numbers in each sample. Blue represents healthy donor samples, orange represents pre-treatment patient samples, and yellow represents post-treatment patient samples

C. UMAP plot of 111,213 PBMCs from all subjects, colored according to the major cell lineages

D. Scatter plot of canonical marker genes for 13 major lineages projected onto the UMAP plot. The red and gray spectra indicate the expression levels of each gene

E. Bar graph showing the proportion of the major cell types for each participant, colored according to the cell type

F. PCA plot of the participants using six clinical variables: ESR, CRP, clinical attachment level, probing pocket depth, plaque index, and gingival index