Fig. 4

Prediction of the polygenic risk score of AS. A Receiver operating characteristic (ROC) curve of the polygenic risk score (PRS) for the prediction of AS. The areas under the ROC curves (AUROCs) for the six PRS methods are reported in the figure legend box. B The distribution of PRSs of the AS cases and controls predicted by the GenEpi method (the blue dashed line represents the median PRS of the control group, and the yellow dashed line represents the median PRS of the case group). C Strata plot of the odds ratio for developing AS generated by different PRS methods. The X-axis shows the range of the decile quantiles, and the Y-axis shows the odds ratio when comparing the PRS of corresponding quantiles (e.g., [90, 100] corresponds to those individuals with PRSs between the 90th and 100th percentile of the cohort population) with the rest of the PRS quantiles of individuals. The bars show the 95% confidence intervals of the odds ratios. D The annotated genes with the consensus SNPs selected by at least three PRS methods in the trained AS-PRS models. The gray blocks indicate that the SNPs were used in the prediction model of the given methods