Fig. 9

High expression of VARS1 correlates with low CD8 T cell infiltration and predict the poor clinical benefit of ICB. (A) The correlation of VARS1 expression and M2-like TAMs infiltration. (B) Correlation between the expression of VARS1 and several known immune checkpoint genes in the TCGA dataset. The correlation coefficients were calculated by the Pearson correlation test. (C) The submap tool analysis showed that VARS1 expression could predict the response to anti-PD-1 treatment. The p values obtained were adjusted by the Bonferroni method. (D) Pan-cancer analysis investigating the correlations between VARS1 expression and CD8 T cell infiltration across 32 cancer types from the TCGA dataset. The correlation coefficients were calculated by the Spearman rank correlation test. (E) Pan-cancer GSEA analysis for immune response related pathway between high- and low-VARS1 tumor tissues. NES, normalized enrichment score; FDR, false discovery rate