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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Transcriptome-based network analysis related to M2-like tumor-associated macrophage infiltration identified VARS1 as a potential target for improving melanoma immunotherapy efficacy

Fig. 4

Multi-omics analysis of two clusters. GISTIC 2.0 analysis determining the statistically significant amplifications and deletions in Cluster1 (A) and Cluster2 (B). Statistically significant gains (red) and losses (blue) of chromosomal locations are shown. The q-value, which characterize statistical significance, are shown below the graph. Areas with q-values < 0.25 (green lines) are considered significantly changed. These peak regions were annotated with known immune checkpoint related genes. (C) Volcano plots show alterations in DNA methylation that are statistically significant between the two clusters. The right side shows different proportions of genomic features

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