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Table 1 Clinicopathological characteristics of patients and samples

From: CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response

Characteristics

N

All

CSPG4 classes

p-value*

low

high

Patient's age, median

 Years (range)

528

61 (2–92)

61 (10–92)

57 (2–90)

0.032

Gender

 Female

299

299 (49%)

151 (47%)

148 (52%)

0.316

 Male

306

306 (51%)

168 (53%)

138 (48%)

Tumor site

 Extremity

206

206 (42%)

124 (47%)

82 (36%)

0.007

 Head and neck

9

9 (2%)

7 (3%)

2 (1%)

 Internal trunk

195

195 (39%)

87 (33%)

108 (47%)

 Superficial trunk

84

84 (17%)

46 (17%)

38 (17%)

Tumor depth

 Deep

144

144 (89%)

73 (88%)

71 (91%)

0.706

 Superficial

17

17 (11%)

10 (12%)

7 (9%)

Pathological type

 Undifferentiated pleomorphic sarcoma

288

288 (21%)

163 (24%)

125 (18%)

7.52E−21

 Leiomyosarcoma

311

311 (23%)

87 (13%)

224 (33%)

 Liposarcoma

476

476 (35%)

259 (38%)

217 (32%)

 Myxofibrosarcoma

100

100 (7%)

78 (12%)

22 (3%)

 Other

177

177 (13%)

86 (13%)

91 (13%)

Pathological tumor size, median cm (range)

170

10.0 (1.2–39.5)

12.53 (1.6–36)

11.8 (1.2–39.5)

0.540

Pathological FNCLCC grade

 1–2

163

163 (49%)

88 (51%)

75 (48%)

0.693

 3

166

166 (51%)

85 (49%)

81 (52%)

Genetic profile

 Simple

508

508 (38%)

269 (40%)

239 (35%)

0.095

 Complex

844

844 (62%)

406 (60%)

438 (65%)

CINSARC risk

Low-risk

724

724 (53%)

381 (55%)

343 (50%)

0.046

High-risk

654

654 (47%)

308 (45%)

346 (50%)

TCGA SARC, iCluster

 1

48

48 (27%)

2 (2%)

46 (51%)

6.51E−14

 2

27

27 (15%)

11 (12%)

16 (18%)

 3

55

55 (30%)

45 (50%)

10 (11%)

 4

9

9 (5%)

7 (8%)

2 (2%)

 5

42

42 (23%)

25 (28%)

17 (19%)

Follow-up median, months (min–max)

610

28 (1–222)

32 (1–203)

24 (1–222)

0.624

DFS event

610

223 (27%)

119 (33%)

104 (43%)

1.28E−02

5-year DFS [95% CI]

610

56% (52–61)

61% (56–68)

49% (42–57)

3.17E−03

  1. The significant p-values are in bold
  2. FNCLCC, Fédération Nationale des Centres de Lutte Contre le Cancer; *, Student’s t-test for continuous variables and Fisher’s exact test for discrete variables