Combined association of triglyceride-glucose index and systolic blood pressure with all-cause and cardiovascular mortality among the general population

Table 3 Univariate and multivariate Cox regression analysis of the combined association of TyG index and SBP (130 mmHg) with all-cause and cardiovascular mortality

Variables	Mortality ATE (per 100,000 person-years)	Univariate analysis	P-value	Multivariate analysis
Variables	Mortality ATE (per 100,000 person-years)	HR (95% CI)	P-value	HR (95% CI)	P-value
All-cause mortality
TyG category
≥ 8.86 (High)	518	Ref.		Ref.
< 8.86 (Low)	257	0.48 (0.37, 0.63)	< 0.001	0.55 (0.39, 0.78)	0.002
SBP category
≥ 130 mmHg	578	Ref.		Ref.
< 130 mmHg	276	0.47 (0.35, 0.63)	< 0.001	0.60 (0.43, 0.85)	0.018
Combined variables
High TyG, SBP ≥ 130 mmHg	671	Ref.		Ref.
High TyG, SBP < 130 mmHg	465	0.69 (0.44, 1.06)	0.056	0.68 (0.42, 1.10)	0.120
Low TyG, SBP ≥ 130 mmHg	515	0.75 (0.46, 1.22)	0.443	0.64 (0.36, 1.15)	0.211
Low TyG, SBP < 130 mmHg	211	0.30 (0.20, 0.46)	< 0.001	0.36 (0.22, 0.60)	< 0.001
P for trend		< 0.001		< 0.001
Cardiovascular mortality
TyG category
≥ 8.55 (High)	69	Ref.		Ref.
< 8.55 (Low)	39	0.42 (0.20, 0.88)	0.037	0.58 (0.31, 0.96)	0.044
SBP category
≥ 130 mmHg	105	Ref.		Ref.
< 130 mmHg	41	0.35 (0.17, 0.73)	0.003	0.44 (0.23, 0.83)	0.008
Combined variables
High TyG, SBP ≥ 130 mmHg	109	Ref.		Ref.
High TyG, SBP < 130 mmHg	56	0.50 (0.20, 1.25)	0.137	0.59 (0.26, 1.36)	0.221
Low TyG, SBP ≥ 130 mmHg	98	0.72 (0.21, 2.48)	0.640	0.83 (0.34, 2.99)	0.992
Low TyG, SBP < 130 mmHg	31	0.19 (0.07, 0.54)	< 0.001	0.32 (0.13, 0.77)	0.003
P for trend		0.001		0.010

Model adjusted for age, gender, BMI, physical activity, HR, current smoker, diabetes, antihypertensive drugs, glucose-lowering drugs, LDL-C, HDL-C, UA, eGFR

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