| Number of liver metastases | p value | Diameter of the metastatic tumor | p value | ||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |  > 1 |  < 3 cm |  ≥ 3 cm | |||||||
Mean ± SD | Median | Mean ± SD | Median | Mean ± SD | Median | Mean ± SD | Median | |||
Primary tumor | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 CD8 | 1.46 ± 1.35 | 1.03 | 1.90 ± 5.96 | 0.66 | 0.947 | 0.62 ± 0.76 | 0.34 | 0.69 ± 0.54 | 0.55 | 0.227 |
 CD68 | 9.66 ± 5.68 | 8.44 | 8.38 ± 4.25 | 9.18 | 0.528 | 3.98 ± 2.91 | 2.71 | 4.47 ± 2.26 | 4.58 | 0.326 |
 PD-L1 | 4.66 ± 3.84 | 3.75 | 3.19 ± 3.50 | 1.88 | 0.044 | 1.94 ± 2.12 | 1.17 | 1.90 ± 1.78 | 1.78 | 0.610 |
 Ki67 | 6.27 ± 6.17 | 4.61 | 3.22 ± 3.28 | 2.10 | 0.096 | 2.15 ± 2.60 | 0.99 | 3.14 ± 3.22 | 2.14 | 0.220 |
 Foxp3 | 0.68 ± 1.32 | 0.28 | 1.08 ± 1.27 | 0.49 | 0.049 | 0.22 ± 0.36 | 0.14 | 0.53 ± 0.67 | 0.21 | 0.029 |
 CD163 | 4.35 ± 2.46 | 3.96 | 3.41 ± 1.87 | 3.12 | 0.117 | 1.54 ± 1.03 | 1.31 | 1.88 ± 1.00 | 1.67 | 0.206 |
 INF-γ | 0.31 ± 0.88 | 0.04 | 0.60 ± 1.17 | 0.02 | 0.481 | 0.21 ± 0.42 | 0.03 | 0.16 ± 0.37 | 0.00 | 0.183 |
 CD20 | 0.64 ± 1.08 | 0.16 | 1.23 ± 1.59 | 0.62 | 0.063 | 0.26 ± 0.32 | 0.13 | 0.40 ± 0.62 | 0.15 | 0.345 |
 CD66b | 12.07 ± 15.07 | 6.48 | 13.82 ± 10.28 | 11.62 | 0.031 | 4.31 ± 2.54 | 4.51 | 4.04 ± 3.00 | 3.49 | 0.396 |
 CD56 | 5.40 ± 6.18 | 3.28 | 5.43 ± 3.31 | 5.61 | 0.108 | 2.46 ± 1.35 | 2.43 | 1.71 ± 1.43 | 1.42 | 0.076 |
 VEGFR-2 | 0.65 ± 0.61 | 0.53 | 0.74 ± 0.93 | 0.31 | 0.485 | 0.25 ± 0.16 | 0.26 | 0.29 ± 0.37 | 0.14 | 0.406 |
 CD11c | 0.45 ± 0.63 | 0.24 | 0.51 ± 0.82 | 0.29 | 0.605 | 0.16 ± 0.14 | 0.12 | 0.20 ± 0.27 | 0.09 | 0.925 |
Liver metastases | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 CD8 | 063 ± 0.56 | 0.49 | 0.70 ± 0.77 | 0.31 | 0.310 | 0.76 ± 0.70 | 0.58 | 1.12 ± 1.61 | 0.53 | 0.806 |
 CD68 | 4.43 ± 2.83 | 3.69 | 3.95 ± 2.18 | 4.24 | 0.863 | 3.92 ± 2.83 | 3.62 | 3.90 ± 2.76 | 3.54 | 0.940 |
 PD-L1 | 2.19 ± 1.95 | 1.84 | 1.54 ± 1.88 | 0.95 | 0.924 | 2.15 ± 1.65 | 1.55 | 2.52 ± 2.71 | 1.58 | 0.985 |
 Ki67 | 3.39 ± 3.39 | 2.11 | 1.65 ± 1.83 | 1.11 | 0.467 | 6.24 ± 9.26 | 1.26 | 8.02 ± 9.26 | 4.83 | 0.187 |
 Foxp3 | 0.32 ± 0.56 | 0.12 | 0.47 ± 0.57 | 0.21 | 0.003 | 0.37 ± 0.28 | 0.37 | 0.76 ± 0.61 | 0.60 | 0.011 |
 CD163 | 1.89 ± 1.07 | 1.76 | 1.47 ± 0.92 | 1.24 | 0.368 | 2.46 ± 1.89 | 2.09 | 2.94 ± 2.81 | 2.00 | 0.880 |
 INF-γ | 0.10 ± 0.18 | 0.02 | 0.31 ± 0.56 | 0.01 | 0.977 | 0.35 ± 0.51 | 0.18 | 0.32 ± 0.70 | 0.05 | 0.290 |
 CD20 | 0.24 ± 0.39 | 0.11 | 0.46 ± 0.62 | 0.33 | 0.061 | 0.41 ± 0.74 | 0.09 | 0.42 ± 1.31 | 0.09 | 0.417 |
 CD66b | 3.56 ± 2.96 | 2.79 | 5.03 ± 2.28 | 5.13 | 0.056 | 2.49 ± 1.36 | 2.17 | 2.85 ± 2.70 | 1.61 | 0.664 |
 CD56 | 1.83 ± 1.50 | 1.68 | 2.39 ± 1.29 | 2.51 | 0.774 | 0.68 ± 0.65 | 0.49 | 1.10 ± 1.59 | 0.46 | 0.685 |
 VEGFR-2 | 0.26 ± 0.20 | 0.24 | 0.29 ± 0.39 | 0.10 | 0.503 | 0.35 ± 0.38 | 0.23 | 0.54 ± 0.85 | 0.17 | 0.720 |
 CD11c | 0.18 ± 0.23 | 0.11 | 0.18 ± 0.20 | 0.13 | 0.479 | 0.51 ± 0.73 | 0.06 | 0.43 ± 0.67 | 0.16 | 0.385 |