Table 1 Uni– and multivariate analyses including TNM, sex, age, location, CEA, grade, Deep-TSR score, Deep-TIL score, and Deep-immune score for OS in the two cohorts

TNM

I

1

1

1

1

II

2.48 (1.12–5.50)

0.025

1.53 (0.54–4.34)

0.400

2.56 (1.01–6.51)

1.14 (0.39–3.36)

III

6.17 (2.87–13.3)

 < 0.001

3.94 (1.44–10.8)

0.008

5.78 (2.33–14.4)

2.70 (0.94–7.79)

Sex

Male

1

1

Female

1.05 (0.71–1.56)

0.800

0.78 (0.33–1.84)

0.600

Age

1.03 (1.01–1.04)

 < 0.001

1.03 (1.01–1.04)

0.001

1.03 (1.01–1.04)

1.03 (1.01–1.04)

Location

Colon

1

1

Rectum

1.00 (0.73–1.37)

0.999

1.48 (1.00–2.21)

0.053

CEA

Normal

1

1

1

1

Abnormal

2.58 (1.87–3.56)

 < 0.001

1.98 (1.35–2.91)

 < 0.001

1.94 (1.40–2.70)

1.46 (0.46–1.18)

Grade

Low

1

1

High

1.44 (0.91–2.28)

0.120

1.80 (1.22–2.67)

0.003

Deep-TSR score

High

1

1

Low

0.62 (0.45–0.86)

0.004

0.57 (0.38–0.85)

0.005

Deep-TIL score

Low

1

1

Middle

0.69 (0.48–0.99)

0.044

0.73 (0.46–1.17)

0.200

High

0.45 (0.30–0.67)

 < 0.001

0.49 (0.31–0.77)

0.002

Deep-immune score

1

1

1

1

1

2

0.68 (0.43–1.08)

0.100

0.72 (0.45–1.14)

0.200

0.67 (0.42–1.10)

0.73 (0.46–1.18)

3

0.48 (0.30–0.77)

0.002

0.48 (0.29–0.79)

0.004

0.54 (0.33–0.90)

0.64 (0.38–1.07)

4

0.27 (0.15–0.48)

 < 0.001

0.31 (0.15–0.62)

 < 0.001

0.36 (0.20–0.66)

0.41 (0.20–0.84)