Skip to main content
Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Decoding the colorectal cancer ecosystem emphasizes the cooperative role of cancer cells, TAMs and CAFsin tumor progression

Fig. 6

Characterization of myeloid cells by scRNA-seq in the SMC cohort. A. UMAP plot of TAMs colored by cell cluster and patient origin. B. Heatmap of marker genes identified through Seurat. For each cell cluster, cells were downsampled to 100. C. Heatmap of well-known macrophage-related immunosuppressive, immune checkpoint and chemokine gene expression across TAMs. D. Heatmap of the top 5 ranked regulons in TAM1-3. E. Dot plot of the correlation between the proportions of C4 cells in epithelial cells and TAM1 (top) or TAM3 (bottom) in the TME. Each dot represents a patient, and a larger size indicates a higher C4 cell proportion. Correlation test is determined using Pearson test

Back to article page