Fig. 5

Dynamic interactions between the EC and MC in the SMC cohort. A. Relative proportions of epithelial cell clusters and TME cell clusters. Samples were clustered according to the distribution pattern of epithelial cells with the corresponding TME cell cluster distribution in the right panel. B. Frequencies of selected cell types for Group C4 and the other groups. The Wilcoxon rank-sum test p value is shown. C. Cell‒cell interactions in tumors (upper panel) and adjacent normal tissues (bottom panel) identified by CellPhoneDB (left). Interactions between cancer cells and nonmalignant cells are highlighted (right). A thicker edge represents more interactions. D. Bar plot of the incoming and outcoming events for epithelial-microenvironment communications in tumors. E. Bubble plots of ligand‒receptor pairs between cancer cells and nonmalignant cells in tumors. The corresponding category is annotated. Dot size and color represent the enrichment score and relative mean expression level of ligand‒receptor pairs, respectively