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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Decoding the colorectal cancer ecosystem emphasizes the cooperative role of cancer cells, TAMs and CAFsin tumor progression

Fig. 4

Validation of the invasive role of C4. A. Ridge plot of expression levels of partial EMT markers across epithelial subclasses. B. Representative IHC images of LAMB3 (upper panel) and ERO1A (bottom panel) staining with the corresponding intensity score (0–3). All the images are at magnification 20 × . C. Overall survival curves for rectal cancer patients with LAMB3+ and LAMB3− staining (left) and ERO1A+ and ERO1A− staining (right) with sample size of each group placed on the bottom. HR, 95%CI and p value are annotated in text. D. Overall survival curves for rectal cancer patients with a LAMB3 + ERO1A+ or LAMB3 + ERO1A− phenotype with sample size of each group placed on the bottom. HR, 95%CI and p value are annotated in text. E. Forest plot of univariate Cox (left) and multivariate Cox (right) analyses of the association of the LAMB3 + ERO1A+ or LAMB3 + ERO1A− phenotype with overall survival. F. Ranks of regulons based on RSS (left) for the C4 group. The C4 group is highlighted in red (middle) and the activated regulon PPARD in dark green (right) in the UMAP plots

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