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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Decoding the colorectal cancer ecosystem emphasizes the cooperative role of cancer cells, TAMs and CAFsin tumor progression

Fig. 3

Functional heterogeneity among CRC epithelial cells in the SMC cohort. A. Volcano plot of differentially expressed genes between colorectal cancer cells and adjacent normal epithelial cells. Genes with FDR values less than 0.05 and absolute log2FC values greater than 1 are colored blue (upregulated in adjacent normal epithelial cells) or red (upregulated in cancer cells). GO enrichment plot is shown on each side, with the bar color indicating the enrichment significance, and bar length showing the number of common genes between the dysregulated genes and GO terms. B. UMAP plot of 18,561 epithelial cells from 23 patients colored by sample origin and CNV level. C. UMAP plot of epithelial cells using 115 cNMF-identified programs. Epithelial cell subclasses are annotated. D. Relative proportions of epithelial cell clusters in adjacent normal tissues and tumor samples of different pathological subtypes. Adenocarcinomas were graded as well, moderately and poorly differentiated. MAC: mucinous adenocarcinoma. E. Boxplot of scEntropy values across epithelial cell clusters. F. Hierarchical heatmap of the 115 expression programs in the SMC cohort. A total of 100 random cells in each cluster were chosen for visualization

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