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Table 3 Baseline values and corresponding changes after 4-week treatment period in women

From: Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trial

Parameter

Baseline values

Change to Week 4

Treamid

Placebo

p-valuea

Treamid

Placebo

Treamid superiority

p-valuea

Borg scale (score)

n = 19

n = 14

 

n = 19

n = 14

  

2.2 ± 0.9

2.1 ± 1.1

0.748 (w)

− 1.2 ± 0.5

− 0.5 ± 0.9

0.7

0.010* (u)

2.0 (2.0; 3.0)

2.0 (1.0; 2.9)

 

− 1.0 (− 1.5; − 1.0)

− 0.5 (− 1.0; 0.0)

0.5

0.005* (m); 0.208 (mr)

6MWD (% pred.)

n = 19

n = 14

 

n = 19

n = 14

  

81.3 ± 15.3

80.9 ± 16.2

0.952 (t)

22.4 ± 23.7

15.5 ± 11.0

6.9%

0.815 (u)

84.6 (76.0; 90.1)

80.4 (74.3; 92.1)

 

13.4 (6.7; 28.3)

14.3 (7.3; 19.7)

− 0.9%

0.883 (m); 0.993 (mr)

TLC (% pred.)

n = 19

n = 14

 

n = 18

n = 14

  

94.6 ± 14.1

102.6 ± 16.9

0.117 (w)

8.1 ± 10.5

− 0.9 ± 5.3

9.0%

0.004* (t)

90.0 (84.8; 105.0)

98.1 (91.5; 105.6)

 

7.6 (− 0.7; 13.7)

− 1.3 (− 5.1; 1.7)

8.9%

0.035* (m); 0.049* (mr)

FVC (% pred.)

n = 19

n = 14

 

n = 19

n = 14

  

85.1 ± 13.8

81.0 ± 9.9

0.502 (w)

3.3 ± 9.3

3.6 ± 6.4

− 0.3%

0.901 (t)

79.0 (75.0; 89.8)

78.0 (75.0; 88.3)

 

4.7 (− 2.4; 9.2)

1.7 (0.0; 6.2)

3%

0.355 (m); 0.436 (mr)

DLCO (% pred.)

n = 19

n = 14

 

n = 18

n = 14

  

73.2 ± 17.3

72.6 ± 12.9

0.536 (w)

10.6 ± 12.6

9.5 ± 17.7

1.1%

0.595 (u)

66.0 (61.6; 77.6)

72.2 (64.9; 78.8)

 

10.3 (− 0.7; 20.0)

5.5 (− 0.9; 13.7)

4.8%

0.483 (m); 0.437 (mr)

Lung damage (%)

n = 19

n = 14

 

n = 19

n = 13

  

27.5 ± 21.5

27.4 ± 24.7

0.739 (w)

− 17.1 ± 11.7

− 10.5 ± 12.6

6.6%

0.073 (u)

25.0 (9.0; 49.0)

24.5 (5.0; 46.2)

 

− 15.0 (− 25.0; − 6.5)

− 5.0 (− 24.0; 0.0)

10.0%

0.039* (m); 0.073 (mr)

  1. Baseline values and change in parameters for women (М ± SD and median (Q1; Q3))
  2. Data in bold indicates significant p-value (< 0.05) according to at least one of the tests used
  3. aTest is put in brackets: m—median test, mr—median regression, t—Student’s t-test, u—Mann–Whitney test