Fig. 5

Prognostic significance of 3 ir-lncRNAs signature in solid cancers. A Forest plot showing HRs for death (overall survival) and corresponding 95%-confidence interval for single sample gene set enrichment scores of the 3 ir-lncRNA signature and the number of patients for each TCGA cancer cohort and RAQA breast cancer cohort. Significant positive HRs are visualized in blue and significant negative HRs are visualized in red. ICR enabled (HR < 1, p-value < 0.05) cancer types are indicated with orange asterisks and ICR disabled (HR > 1, p-value < 0.05) cancers are indicated with purple asterisks. B Overall survival Kaplan–Meier curves of selected cancers, dichotomized by the enrichment score of the 3 ir-lncRNAs signature. Dichotomization cutoff of ‘high’ (red) and ‘low’ (cyan) subgroups was based on optimal cut-off points as determined by fivefold cross validation analysis. Cancer types in which the 3 ir-lncRNA signature holds significant prognostic value according to the logrank test were selected for visualization. Censor points are indicated by vertical lines