Fig. 5

CRs genetic interactions induce multiple omics deregulation in TCGA. A CSL interactions disrupt gene expression, DNA methylation, homologous recombination repair ability and immune cell infiltration in TCGA. B CSV interactions disrupt gene expression, DNA methylation, homologous recombination repair ability and immune cell infiltration in TCGA. Red or green entries represent the number of up-regulated or down-regulated genes and hyper-methylated or hypo-methylated DNA. Differentially methylated genes or differentially expressed gene were identified using one-sided Wilcoxon rank-sum test with FDR < 0.1. Yellow entries indicate up-regulation of the HRD score or TIL, and purple entries imply down regulation of the HRD score or TIL. Heatmap of the HRD score and TIL shows the –logP, where P values were calculated by one-sided Wilcoxon rank-sum test