Fig. 4

Functional analysis of CRs genetic interactions. The co-expression analysis for CSL interaction (A) and CSV interaction (D) were investigated in TCGA. The co-methylation analysis for CSL interaction (B) and CSV interaction (E) were investigated in TCGA. The co-expressed interaction and co-methylaetd interaction were detected, respectively for CSL (C) and CSV (F). The drug therapeutic similarity score of similar drug pairs and other drug pairs in CSL (G) and CSV (K) map were showed. Similarity of drug targets in terms of BP (H), MF (I) and CC (J) in CSL map was detected. Similarity of drug targets in terms of their BP (L), MF (M) and CC (N) in CSV map was detected. P values were calculated by t test in G-N